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欧盟评价来自一种米曲霉的α-淀粉酶的保险性

缩小字体  缩小字体 时光:2019-11-28 16:29 起源:食物伙伴网 作者: 可心   
中心提醒:2019年11月27日,欧盟食物保险局就来自米曲霉(Aspergillus oryzae)菌株DP‐Bzb41的α-淀粉酶(α-amylase)的保险性评估发布看法。
  食物伙伴网讯  2019年11月27日,欧盟食物保险局就来自米曲霉(Aspergillus oryzae)菌株DP‐Bzb41的α-淀粉酶(α-amylase)的保险性评估发布看法。
 
  据懂得,该种食物酶是由美国公司Danisco US Inc.应用米曲霉菌株DP‐Bzb41出产的,旨在用于食物烘焙和酿造工艺、蒸馏酒精出产和用于出产葡萄糖浆的淀粉加工中。经由评价,欧盟专家小组得出论断以为,在预期应用条件下,这种食物酶不会惹起保险成绩。 局部原文报道如下:
 
  The food enzyme α‐amylase (4‐α‐d‐glucan glucanohydrolase, EC 3.2.1.1) is produced with a non‐genetically modified Aspergillus oryzae (strain DP‐Bzb41) by Danisco US Inc. (USA)。 The α‐amylase food enzyme is intended to be used in baking, brewing, distilled alcohol production and starch processing for the glucose syrup production. based on the maximum use levels for baking and brewing processes and individual data from the EFSA Comprehensive European Food Database, dietary exposure to the food enzyme-Total Organic Solids (TOS) was estimated to be up to 2.59 mg TOS/kg body weight (bw) per day. Since residual amounts of TOS are removed during distilled alcohol production and by the purification steps applied during starch processing, dietary exposure for these processes was not calculated. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level (NOAEL) of 1,000 mg TOS/kg bw per day, the highest dose tested. Comparison with the estimated dietary exposure, results in a margin of exposure of at least 386. Similarity of the amino acid sequence to those of known allergens was searched and one match to respiratory allergen was found (an amylase from another strain of A. oryzae)。 The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
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日期:2019-11-28
 
 
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